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[1] Dose escalation is discouraged if tolerance develops; therapy is usually discontinued in lieu of enhanced. Renal or hepatic impairment may perhaps necessitate lessen starting up doses. During remedy, checking of pounds, coronary heart price, and hypertension is critical. A benchmark for clinical reaction is lack of at least 3-4 kg in the initial month; if that's not obtained, ongoing use should be reevaluated.
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